HLA class II genotypes are not associated with age related macular degeneration in a case-control, population-based study
| Autor: | Pappas, Derek, Hollenbach, Jill, Coleman, Anne L, Gorin, Michael B, Yu, Fe, Williams, Kevin, Noble, Janelle, Tranah, Gregory J, Study of Osteoporotic Fractures (SOF) Research Group |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Aging Immunology AMD Neurodegenerative HLA-DQ alpha-Chains Macular Degeneration Genetic Population Groups Clinical Research Next generation sequencing 80 and over Genetics Humans HLA-DQ beta-Chains 2.1 Biological and endogenous factors Genetic Predisposition to Disease Polymorphism Aetiology Age related macular degeneration Eye Disease and Disorders of Vision Genetic Association Studies HLA-DP beta-Chains Aged Class II screening and diagnosis 4.1 Discovery and preclinical testing of markers and technologies HLA Detection Study of Osteoporotic Fractures (SOF) Research Group Case-Control Studies Female HLA-DRB1 Chains |
| Zdroj: | Human immunology, vol 76, iss 2-3 |
| Popis: | Multiple lines of evidence support an immunologic basis and genetic disposition for the development of age-related macular degeneration (AMD). Comprehensive human leukocyte antigens (HLA) class II typing at four loci (DRB1, DQA1, DQB1, and DPB1) was assessed using next generation sequencing methods and tested for association with age-related macular degeneration (AMD) in a case-control study of 456 AMD cases and 499 controls from the population-based Study of Osteoporotic Fractures (SOF) cohort. No statistically significant associations were identified for any of the class II loci and a previously identified association between DRB1*13:01 was not replicated in this dataset. These results reported here suggest that common HLA class II genetic variation does not contribute to AMD disease risk. |
| Databáze: | OpenAIRE |
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