Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes theintegrated stress response

Autor: Renslo, Adam, Walter, Peter, Sidrauski, C, Tsai, JC, Kampmann, M, Hearn, BR, Vedantham, P, Jaishankar, P, Sokabe, M, Mendez, AS, Newton, BW, Tang, EL
Jazyk: angličtina
Rok vydání: 2015
Zdroj: Renslo, Adam; Walter, Peter; Sidrauski, C; Tsai, JC; Kampmann, M; Hearn, BR; et al.(2015). Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes theintegrated stress response. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1n22h5zs
Popis: © 2015, eLife. All rights reserve.The general translation initiation factor eIF2 is a major translational control point. Multiple signaling pathways in the integrated stress response phosphorylate eIF2 serine-51, inhibiting nucleotide exchange by eIF2B. IS
Databáze: OpenAIRE