Impact of Age and Sex on Response to Asthma Therapy
| Autor: | Dunn, Ryan M, Lehman, Erik, Chinchilli, Vernon M, Martin, Richard J, Boushey, Homer A, Israel, Elliot, Kraft, Monica, Lazarus, Stephen C, Lemanske, Robert F, Lugogo, Njira L, Peters, Stephen P, Sorkness, Christine A, Szefler, Stanley, Wechsler, Michael E, NHLBI Asthma Clinical Research Network |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Aging NHLBI Asthma Clinical Research Network Respiratory System inhaled corticosteroid Medical and Health Sciences Cohort Studies Sex Factors Clinical Research Odds Ratio Humans sex Treatment Failure Budesonide Glucocorticoids Lung Retrospective Studies Beclomethasone Age Factors asthma Bronchodilator Agents Treatment Outcome Logistic Models Phenotype Inhalation age Administration Respiratory Leukotriene Antagonists Female |
| Zdroj: | American journal of respiratory and critical care medicine, vol 192, iss 5 |
| Popis: | RationaleAge and sex are associated with differences in asthma prevalence and morbidity.ObjectivesTo determine if age and sex associate with distinct phenotypes and a variable response to therapy in subjects with mild to moderate asthma.MethodsWe used Asthma Clinical Research Network data to determine the impact of age and sex on phenotypes and treatment failures among subjects participating in 10 trials from 1993 to 2003.Measurements and main resultsA total of 1,200 subjects were identified (median age, 30.4 yr; male, 520 [43.3%]; female, 680 [56.7%]) and analyzed. A higher proportion of subjects greater than or equal to 30 years old experienced treatment failures (17.3% vs. 10.3%; odds ratio [OR], 1.82; confidence interval [CI], 1.30-2.54; P |
| Databáze: | OpenAIRE |
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