Early mixed chimerism-based preemptive immunotherapy in children undergoing allogeneic hematopoietic stem cell transplantation for acute leukemia
| Autor: | Horn, Biljana, Wahlstrom, Justin T, Melton, Alexis, Liou, Angela, Ouachee-Chardin, Marie, Sunkersett, Gauri, Willert, Jennifer, Hwang, Jimmy, Expose-Spencer, Jueleah, Cowan, Mort C, Facchino, Janelle, Dvorak, Christopher C |
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| Rok vydání: | 2017 |
| Předmět: |
Homologous
Male Myeloid Adolescent Clinical Trials and Supportive Activities Clinical Sciences Oncology and Carcinogenesis Kaplan-Meier Estimate Acute Regenerative Medicine Disease-Free Survival Paediatrics and Reproductive Medicine Young Adult Rare Diseases Stem Cell Research - Nonembryonic - Human Clinical Research Humans Oncology & Carcinogenesis Child Preschool Retrospective Studies Cancer allogeneic stem cell transplant Pediatric Transplantation Chimera Transplantation Leukemia Hematopoietic Stem Cell Transplantation Infant Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Stem Cell Research Neoplasm Recurrence Local Transplantation Tolerance Female pediatric leukemia Immunotherapy immunotherapy |
| Zdroj: | Pediatric blood & cancer, vol 64, iss 8 |
| Popis: | This retrospective analysis comprises 10-year experience with early posttransplant mixed chimerism-based preemptive intervention. Out of 104 patients, 51 received preemptive immunotherapy. Their outcomes were similar to patients achieving full donor chimerism spontaneously. Among patients receiving intervention, 5-year event-free survival was identical in patients with and without pretransplant residual disease, respectively (68% [95% confidence interval (CI) 38-98%] vs. 69% [95% CI 54-85%] log-rank = 0.4). In patients who received preemptive immunotherapy, chimerism status and residual disease prior to transplant were no longer predictors of poor outcome; however, 41% of the patients with residual disease prior to transplant relapsed early and did not benefit from this strategy. |
| Databáze: | OpenAIRE |
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