Subclinical cardiovascular disease in HIV controller and long-term nonprogressor populations
| Autor: | Brusca, RM, Hanna, DB, Wada, NI, Blankson, JN, Witt, MD, Jacobson, LP, Kingsley, L, Palella, FJ, Budoff, M, Brown, TT, Anastos, K, Lazar, JM, Mack, WJ, Bacchetti, P, Tien, PC, Golzar, Y, Plankey, M, Golub, E, Kaplan, RC, Post, WS |
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| Rok vydání: | 2020 |
| Předmět: |
Carotid Artery Diseases
Adult Male carotid atherosclerosis Clinical Sciences Lipopolysaccharide Receptors HIV Infections Cardiovascular Carotid Intima-Media Thickness subclinical cardiovascular disease HIV Long-Term Survivors Cohort Studies Young Adult Clinical Research Virology Receptors Humans Multicenter Studies as Topic Antigens Tomography Heart Disease - Coronary Heart Disease Prevention HIV coronary atherosclerosis Myelomonocytic Middle Aged Atherosclerosis CD X-Ray Computed CD4 Lymphocyte Count AIDS Observational Studies as Topic Heart Disease Good Health and Well Being Differentiation Cell Surface HIV/AIDS Calcium Female Infection Biomarkers |
| Zdroj: | HIV medicine, vol 21, iss 4 |
| Popis: | ObjectivesElite controllers (ECs), viraemic controllers (VCs), and long-term nonprogressors (LTNPs) control HIV viral replication or maintain CD4 T-cell counts without antiretroviral therapy, but may have increased cardiovascular disease (CVD) risk compared to HIV-uninfected persons. We evaluated subclinical carotid and coronary atherosclerosis and inflammatory biomarker levels among HIV controllers, LTNPs and noncontrollers and HIV-uninfected individuals in the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study (WIHS).MethodsWe measured carotid plaque presence and common carotid artery intima-media thickness (IMT) in 1729 women and 1308 men, and the presence of coronary artery calcium and plaque in a subgroup of men. Associations between HIV control category and carotid and coronary plaque prevalences were assessed by multivariable regression analyses adjusting for demographics and CVD risk factors. Serum inflammatory biomarker concentrations [solubleCD163(sCD163), soluble CD14 (sCD14), galectin-3 (Gal-3), galectin-3binding protein (Gal-3BP) and interleukin (IL)-6] were measured and associations with HIV control category assessed.ResultsWe included 135 HIV controllers (30 ECs) and 135 LTNPs in the study. Carotid plaque prevalence and carotid IMT were similar in HIV controllers, LTNPs and HIV-uninfected individuals. HIV controllers and LTNPs had lower prevalences of carotid plaque compared to viraemic HIV-infected individuals. The prevalence of coronary atherosclerosis was similar in HIV controllers/LTNPs compared to HIV-uninfected and viraemic HIV-infected men. Controllers and LTNPs had higher concentrations of sCD163 and sCD14 compared to HIV-uninfected persons.ConclusionsSubclinical CVD was similar in HIV controllers, LTNPs and HIV-uninfected individuals despite elevated levels of some inflammatory biomarkers. Future studies of HIV controllers and LTNPs are needed to characterize the risk of CVD among HIV-infected persons. |
| Databáze: | OpenAIRE |
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