HIV-1C and HIV-1B Tat protein polymorphism in Southern Brazil
| Autor: | de Almeida, Sérgio Monteiro, Rotta, Indianara, Vidal, Luine Rosele Renaud, Dos Santos, Jucelia Stadinicki, Nath, Avindra, Johnson, Kory, Letendre, Scott, Ellis, Ronald J, H. I. V. Neurobehavioral Research Center (HNRC) Group |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Dicysteine Clinical Sciences Neurosciences Single Nucleotide Middle Aged Subtype C Cross-Sectional Studies H. I. V. Neurobehavioral Research Center (HNRC) Group Medical Microbiology Virology HIV-1 Genetics Humans Neuropathogenesis HIV/AIDS Female Tat Polymorphism tat Gene Products Infection Brazil Human Immunodeficiency Virus |
| Zdroj: | Journal of neurovirology, vol 27, iss 1 |
| Popis: | The transactivator of transcription (Tat) is a key HIV regulatory protein. We aimed to identify the frequency of key polymorphisms in HIV-1C compared with HIV-1B Tat protein, chiefly in the cysteine-, arginine-, and glutamine-rich domains and identify novel point mutations in HIV-1B and C sequences from Southern Brazil. This study was the first to investigate the genetic diversity and point mutations within HIV-1 Tat C in a Brazilian cohort. This was an observational, cross-sectional study, which included sequences of HIV-1B (n = 20) and HIV-1C (n = 21) from Southern Brazil. Additionally, 344 HIV-1C sequences were obtained from the Los Alamos database: 29 from Brazil and 315 from Africa, Asia, and Europe. The frequency of C31S substitution on HIV-1 Tat C in Brazil was 82% vs. 10% in the HIV-1B group (p |
| Databáze: | OpenAIRE |
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