Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischaemic injury in rats
| Autor: | Shrestha, Ayush, Krishnamurthy, Praveen T, Thomas, Pooja, Hammock, Bruce D, Hwang, Sung H |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Cardiotonic Agents Medical Physiology Wistar Myocardial Infarction ischaemic injury t-TUCB Cardiovascular Benzoates Antioxidants Heart Conduction System Animals Pharmacology & Pharmacy Nutrition Epoxide Hydrolases isoproterenol Myocardium Phenylurea Compounds Prevention Heart Organ Size Pharmacology and Pharmaceutical Sciences Rats Oxidative Stress soluble epoxide hydrolase inhibitor Heart Disease Reperfusion Injury Lipid Peroxidation Biomarkers |
| Zdroj: | The Journal of pharmacy and pharmacology, vol 66, iss 9 |
| Popis: | ObjectivesTo determine the protective role of a soluble epoxide hydrolase(sEH) inhibitor, trans-4-{4-[3-(4-trifluoromethoxyphenyl)-ureido] cyclohexyloxy} benzoic acid (t-TUCB), in isoproterenol (ISO)-induced myocardial ischaemic injury in vivo.MethodsCardioprotective activity of t-TUCB was studied against ISO-induced myocardial ischaemic injury in male Wistar rats. Cardioprotection was assessed by measuring elecrocardiographic (EKG), serum lactate dehydrogenase (LDH) and creatine kinase (CK-MB) levels, cardiac calcium and antioxidant levels, and also by measuring infarct size in the cardiac tissue.Key findingsPretreatment with t-TUCB at 3, 10 and 30 mg/kg orally for a period of 14 days significantly prevented the changes in EKG parameters (QTc interval prolongation, ST height depression, pathological Q waves formation and T-wave inversion), serum cardiac biomarkers (CK-MB and LDH), relative heart weight, myocardial calcium levels, infarct size and the oxidative status in the cardiac tissue (lipid peroxidation, catalase and superoxide dismutase levels) when compared with the untreated control animals (P |
| Databáze: | OpenAIRE |
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