The relationship of the bronchodilator response phenotype to poor asthma control in children with normal spirometry
| Autor: | Galant, Stanley P, Morphew, Tricia, Newcomb, Robert L, Hioe, Kiem, Guijon, Olga, Liao, Otto |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
pharmacology [Adrenal Cortex Hormones] Adolescent metabolism [Nitric Oxide] methods [Spirometry] Exhalation Forced Expiratory Volume therapy [Asthma] Medicine and Health Sciences Odds Ratio Humans Regression Analysis Female Child pharmacology [Bronchodilator Agents] methods [Pulmonary Medicine] |
| Zdroj: | Galant, Stanley P; Morphew, Tricia; Newcomb, Robert L; Hioe, Kiem; Guijon, Olga; & Liao, Otto. (2011). The relationship of the bronchodilator response phenotype to poor asthma control in children with normal spirometry.. The Journal of pediatrics, 158(6), 953-9959.e1. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/9jj0f7xg |
| Popis: | To determine the relationship of poor asthma control to bronchodilator response (BDR) phenotypes in children with normal spirometry. Children with asthma were assessed for clinical indexes of poorly controlled asthma. Pre- and post-bronchodilator spirometry were performed, and the percent BDR was determined. Multivariate logistic regression assessed the relationship of the clinical indices to BDR at ≥ 8%, ≥ 10%, and ≥ 12% BDR thresholds. There were 510 controller naïve children and 169 on controller medication. In the controller naïve population the mean age (± 1 SD) was 9.5 (3.4); 57.1% were male, 85.7% Hispanic. Demographics were similar in both populations. In the adjusted profile, significant clinical relationships were found particularly to positive BDR phenotypes ≥ 10% and ≥ 12% versus negative responses including younger age, (OR 2.0, 2.5; P < .05), atopy (OR 1.9, 2.6; P < .01), nocturnal symptoms in females (OR 3.4, 3.8; P < .01); β₂ agonist use (OR 1.7, 2.8; P < .01); and exercise limitation (OR 2.2, 2.5; P < .01) only in the controller naïve population. The BDR phenotype ≥ 10% is significantly related to poor asthma control, providing a potentially useful objective tool in controller naïve children even when the pre-bronchodilator spirometry result is normal. |
| Databáze: | OpenAIRE |
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