Age-associated changes in the mechanical properties of human cadaveric pelvic floor muscles
| Autor: | Burnett, Lindsey A, Cook, Mark, Shah, Sameer, Michelle Wong, Ms, Kado, Deborah M, Alperin, Marianna |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Urologic Diseases Aging Mechanical Engineering Pelvic floor disorders Passive mechanics Biomedical Engineering Pelvic Floor Human Movement and Sports Sciences Middle Aged Pelvic Floor Disorders Extracellular Matrix Pelvic floor muscles Stiffness Young Adult Clinical Research Musculoskeletal Cadaver Humans Female Muscle Contraction Aged |
| Popis: | Proper function of the female pelvic floor requires intact pelvic floor muscles (PFMs). The prevalence of pelvic floor disorders (PFDs) increases substantially with age, in part due to clinically identified deterioration of PFM function with age. However, the etiology of this decline remains largely unknown. We previously demonstrated that PFMs undergo age-related fibrotic changes. This study sought to determine whether aging also impacts PFMs' passive mechanical properties that are largely determined by the intramuscular extracellular matrix. Biopsies from younger (≤52y) and older (>52y) female cadaveric donors were procured from PFMs, specifically coccygeus (C) and two portions of the levator ani - iliococcygeus (IC) and pubovisceralis (PV), and the appendicular muscles - obturator internus (OI) and vastus lateralis (VL). Muscle bundles were subjected to a passive loading protocol, and stress-sarcomere length (Ls) relationships calculated. Muscle stiffness was compared between groups using 2-way ANOVA and Sidak pairwise comparisons, α |
| Databáze: | OpenAIRE |
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