Commonfolate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment

Autor: Weiner, Michael, Rajagopalan, P, Jahanshad, N, Stein, JL, Hua, X, Madsen, SK, Kohannim, O, Hibar, DP, Toga, AW, Jack, CR, Saykin, AJ
Jazyk: angličtina
Rok vydání: 2012
Zdroj: Weiner, Michael; Rajagopalan, P; Jahanshad, N; Stein, JL; Hua, X; Madsen, SK; et al.(2012). Commonfolate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8650z9sx
Popis: A commonly carried C677T polymorphism in a folate-related gene, MTHFR, is associated with higher plasma homocysteine, a well-known mediator of neuronal damage and brain atrophy. As homocysteine promotes brain atrophy, we set out to discover whether people
Databáze: OpenAIRE