Mitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults
| Autor: | Tranah, Gregory J, Yaffe, Kristine, Katzman, Shana M, Lam, Ernest T, Pawlikowska, Ludmila, Kwok, Pui-Yan, Schork, Nicholas J, Manini, Todd M, Kritchevsky, Stephen, Thomas, Fridtjof, Newman, Anne B, Harris, Tamara B, Coleman, Anne L, Gorin, Michael B, Helzner, Elizabeth P, Rowbotham, Michael C, Browner, Warren S, Cummings, Steven R, Health, Aging and Body Composition Study |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Aging Mitochondrial Diseases Mobility Vision 1.1 Normal biological development and functioning Clinical Sciences Neurodegenerative Heteroplasmy Cohort Studies Cognition Hearing Clinical Research Underpinning research Neurologic Genetics Humans Gait Disorders Mobility Limitation Eye Disease and Disorders of Vision Aged Neurosciences DNA Mitochondrial DNA Mitochondrial Brain Disorders Good Health and Well Being Health Sensation Disorders Female Aging and Body Composition Study Cognition Disorders Gerontology |
| Zdroj: | The journals of gerontology. Series A, Biological sciences and medical sciences, vol 70, iss 11 |
| Popis: | BackgroundMitochondrial DNA (mtDNA) heteroplasmy is a mixture of normal and mutated mtDNA molecules in a cell. High levels of heteroplasmy at specific mtDNA sites lead to inherited mitochondrial diseases with neurological, sensory, and movement impairments. Here we test the hypothesis that heteroplasmy levels in elderly adults are associated with impaired function resembling mild forms of mitochondrial disease.MethodsWe examined platelet mtDNA heteroplasmy at 20 disease-causing sites for associations with neurosensory and mobility function among 137 participants from the community-based Health, Aging, and Body Composition Study.ResultsElevated mtDNA heteroplasmy at four mtDNA sites in complex I and tRNA genes was nominally associated with reduced cognition, vision, hearing, and mobility: m.10158T>C with Modified Mini-Mental State Examination score (p = .009); m.11778G>A with contrast sensitivity (p = .02); m.7445A>G with high-frequency hearing (p = .047); and m.5703G>A with 400 m walking speed (p = .007).ConclusionsThese results indicate that increased mtDNA heteroplasmy at disease-causing sites is associated with neurosensory and mobility function in older persons. We propose the novel use of mtDNA heteroplasmy as a simple, noninvasive predictor of age-related neurologic, sensory, and movement impairments. |
| Databáze: | OpenAIRE |
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