Mindfulness, Education, and Exercise for age-related cognitive decline: Study protocol, pilot study results, and description of the baseline sample
| Autor: | Wetherell, Julie Loebach, Ripperger, Hayley S, Voegtle, Michelle, Ances, Beau M, Balota, David, Bower, Emily S, Depp, Colin, Eyler, Lisa, Foster, Erin R, Head, Denise, Hershey, Tamara, Hickman, Steven, Kamantigue, Noralinda, Klein, Samuel, Miller, J Philip, Yingling, Michael D, Nichols, Jeanne, Nicol, Ginger E, Patterson, Bruce W, Rodebaugh, Thomas L, Shimony, Joshua S, Snyder, Abraham, Stephens, Mary, Tate, Susan, Uhrich, Mary L, Wing, David, Wu, Gregory F, Lenze, Eric J, MEDEX Research Group |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Aging intervention study 6.6 Psychological and behavioural Statistics & Probability Clinical Trials and Supportive Activities Clinical Sciences Pilot Projects elderly Cognition MEDEX Research Group Memory Clinical Research Behavioral and Social Science Complementary and Integrative Health Humans Cognitive Dysfunction Exercise Health Education Aged Randomized Controlled Trials as Topic Prevention Rehabilitation Statistics Evaluation of treatments and therapeutic interventions Magnetic Resonance Imaging Quality Education Treatment Outcome Meditation aerobic exercise Mental Health Cognitive Aging Female Mindfulness Mind and Body |
| Zdroj: | Clinical trials (London, England), vol 17, iss 5 |
| Popis: | Background/aimsAge-related cognitive decline is a pervasive problem in our aging population. To date, no pharmacological treatments to halt or reverse cognitive decline are available. Behavioral interventions, such as physical exercise and Mindfulness-Based Stress Reduction, may reduce or reverse cognitive decline, but rigorously designed randomized controlled trials are needed to test the efficacy of such interventions.MethodsHere, we describe the design of the Mindfulness, Education, and Exercise study, an 18-month randomized controlled trial that will assess the effect of two interventions-mindfulness training plus moderate-to-vigorous intensity exercise or moderate-to-vigorous intensity exercise alone-compared with a health education control group on cognitive function in older adults. An extensive battery of biobehavioral assessments will be used to understand the mechanisms of cognitive remediation, by using structural and resting state functional magnetic resonance imaging, insulin sensitivity, inflammation, and metabolic and behavioral assessments.ResultsWe provide the results from a preliminary study (n = 29) of non-randomized pilot participants who received both the exercise and Mindfulness-Based Stress Reduction interventions. We also provide details on the recruitment and baseline characteristics of the randomized controlled trial sample (n = 585).ConclusionWhen complete, the Mindfulness, Education, and Exercise study will inform the research community on the efficacy of these widely available interventions improve cognitive functioning in older adults. |
| Databáze: | OpenAIRE |
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