Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year
| Autor: | Winchester, J, Dick, MB, Gillen, D, Reed, B, Miller, B, Tinklenberg, J, Mungas, D, Chui, H, Galasko, D, Hewett, L, Cotman, CW |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Aging Clinical Trials and Supportive Activities Clinical Sciences Cognitive decline Walking Neuropsychological Tests Neurodegenerative Alzheimer's Disease Cardiovascular MMSE Mild impairment Cognition Alzheimer Disease Clinical Research Activities of Daily Living Behavioral and Social Science Acquired Cognitive Impairment Humans Exercise Aged Psychiatric Status Rating Scales Depression Physical activity Prevention Rehabilitation Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Middle Aged Alzheimer's Exercise Therapy Brain Disorders Mental Health Geriatrics Neurological Female Dementia Mental health Mind and Body |
| Zdroj: | Archives of gerontology and geriatrics, vol 56, iss 1 |
| Popis: | AD is a public health epidemic, which seriously impacts cognition, mood and daily activities; however, one type of activity, exercise, has been shown to alter these states. Accordingly, we sought to investigate the relationship between exercise and mood, in early-stage AD patients (N=104) from California, over a 1-year period. Patients completed the Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS), and Blessed-Roth Dementia Rating Scale (BRDRS), while their caregivers completed the Yale Physical Activity Survey (YALE), Profile of Mood States (POMS), the Neuropsychiatric Inventory (NPI) and Functional Abilities Questionnaire (FAQ). Approximately half of the participants were female, from a variety of ethnic groups (Caucasian=69.8%; Latino/Hispanic Americans=20.1%). Our results demonstrated that the patients spent little time engaged in physical activity in general, their overall activity levels decreased over time, and this was paired with a change in global cognition (e.g., MMSE total score) and affect/mood (e.g., POMS score). Patients were parsed into Active and Sedentary groups based on their Yale profiles, with Active participants engaged in walking activities, weekly, over 1 year. Here, Sedentary patients had a significant decline in MMSE scores, while the Active patients had an attenuation in global cognitive decline. Importantly, among the Active AD patients, those individuals who engaged in walking for more than 2 h/week had a significant improvement in MMSE scores. Structured clinical trials which seek to increase the amount of time AD patients were engaged in walking activities and evaluate the nature and scope of beneficial effects in the brain are warranted. |
| Databáze: | OpenAIRE |
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