Haptoglobin 2 Allele is Associated With Histologic Response to Vitamin E in Subjects With Nonalcoholic Steatohepatitis
Autor: | Banini, Bubu A, Cazanave, Sophie C, Yates, Katherine P, Asgharpour, Amon, Vincent, Robert, Mirshahi, Faridoddin, Le, Peter, Contos, Melissa J, Tonascia, James, Chalasani, Naga P, Kowdley, Kris V, McCullough, Arthur J, Behling, Cynthia A, Schwimmer, Jeffrey B, Lavine, Joel E, Sanyal, Arun J, Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male nonalcoholic fatty liver disease Genotype Clinical Trials and Supportive Activities Chronic Liver Disease and Cirrhosis Clinical Sciences vitamin E haptoglobin genotype Oral and gastrointestinal Hepatitis Non-alcoholic Fatty Liver Disease Clinical Research Complementary and Integrative Health Humans oxidative stress nonalcoholic steatohepatitis Alleles Randomized Controlled Trials as Topic Haptoglobins Gastroenterology & Hepatology Liver Disease Treatment Outcome Nonalcoholic Steatohepatitis Clinical Research Network Female Digestive Diseases |
Zdroj: | Journal of clinical gastroenterology, vol 53, iss 10 |
Popis: | BackgroundHaptoglobin (Hp) genotype has been linked to oxidative stress and cardiovascular outcomes in response to vitamin E (VitE) among patients with diabetes mellitus. Its effect on histologic response to VitE in nonalcoholic steatohepatitis (NASH) is unknown.GoalsOur objective was to determine if Hp genotype associates with response to VitE in patients with NASH.StudyA post hoc analysis of 228 patients receiving VitE or placebo in 2 clinical trials was performed. Regression analysis was used to assess the effect of VitE versus placebo, by Hp genotype (1-1, 2-1, or 2-2), on histologic features and laboratory markers of nonalcoholic fatty liver disease, comparing baseline to end of treatment values. An interaction term was included in the regression models to assess differential treatment effect across Hp genotype.ResultsHp 2-2 patients treated with VitE versus placebo showed significant histologic improvement (51% vs. 20%; OR=4.2; P=0.006), resolution of steatohepatitis (44% vs. 12%; OR=6.2; P=0.009), decrease in nonalcoholic fatty liver disease Activity Score (NAS) (-2.2 vs. -0.6; P=0.001), and decrease in liver enzymes alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transpeptidase. Hp 2-1 patients on VitE versus placebo showed improved resolution of steatohepatitis, NAS and liver enzymes. Hp 1-1 patients showed no significant improvement in histology or liver enzymes. VitE had no effect on fibrosis stage in any group. Regression analysis showed incremental benefit of having Hp 2-2 or 2-1 versus 1-1 for all liver enzyme.ConclusionsHp 2 allele is associated with greater histologic and biological improvement in NASH with VitE treatment compared with the Hp 1 allele. |
Databáze: | OpenAIRE |
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