Testosterone is Associated With Nonalcoholic Steatohepatitis and Fibrosis in Premenopausal Women With NAFLD
| Autor: | Sarkar, Monika A, Suzuki, Ayako, Abdelmalek, Manal F, Yates, Katherine P, Wilson, Laura A, Bass, Nathan M, Gill, Ryan, Cedars, Marcelle, Terrault, Norah, NASH Clinical Research Network |
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| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
Adult Aging Nonalcoholic Fatty Liver Disease Chronic Liver Disease and Cirrhosis Clinical Trials and Supportive Activities Clinical Sciences Oral and gastrointestinal Hepatitis Non-alcoholic Fatty Liver Disease Clinical Research Sex Hormones NASH Clinical Research Network Humans Testosterone Abdominal Obesity Nutrition Gastroenterology & Hepatology Liver Disease Contraception/Reproduction Fibrosis Good Health and Well Being Liver Hepatic Inflammation Androgens Female Abdominal Adiposity Digestive Diseases |
| Zdroj: | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, vol 19, iss 6 |
| Popis: | Background & aimsHigher testosterone contributes to imaging-confirmed nonalcoholic fatty liver disease (NAFLD) in women, but whether testosterone influences their disease severity is unknown.MethodsThe association of free testosterone (free T) with nonalcoholic steatohepatitis (NASH) was determined in pre-menopausal women with biopsy-confirmed NAFLD (n = 207). Interaction testing was performed for age and free T given decline in testosterone with age, and association of aging with NASH. Regression models adjusted for abdominal adiposity, diabetes, and dyslipidemia.ResultsMedian age was 35 yrs (interquartile range, 29-41); 73% were white, 25% Hispanic; 32% had diabetes, 93% abdominal adiposity, and 95% dyslipidemia. 69% had NASH, 67% any fibrosis, and 15% advanced fibrosis. Higher free T levels were associated with NAFLD severity in younger women (interaction P value |
| Databáze: | OpenAIRE |
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