| Autor: |
Vehmas, AK, Kawas, CH, Stewart, WF, Troncoso, JC |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Vehmas, AK; Kawas, CH; Stewart, WF; & Troncoso, JC. (2003). Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease. Neurobiology of Aging, 24(2), 321-331. doi: 10.1016/S0197-4580(02)00090-8. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/690322xk |
| Popis: |
We examined the associations of postmortem neocortical immunoreactivities for microglia, astrocytes, Aβ and Tau with cognitive changes in clinically characterized subjects with pathological diagnoses (CERAD classification) of definite AD (9), possible AD (15) and age-matched controls (11). By measuring the fractional area (FA) of immunoreactivity, we found that Aβ deposits appear early in the pathogenesis of Aβ, but cannot account for cognitive decline. We found a significant increases in FA for microglia in possible AD cases (nondemented) compared to controls (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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