Accuracy of common proton density fat fraction thresholds for magnitude- and complex-based chemical shift-encoded MRI for assessing hepatic steatosis in patients with obesity
| Autor: | Cunha, Guilherme Moura, Thai, Tydus T, Hamilton, Gavin, Covarrubias, Yesenia, Schlein, Alexandra, Middleton, Michael S, Wiens, Curtis N, McMillan, Alan, Agni, Rashmi, Funk, Luke M, Campos, Guilherme M, Horgan, Santiago, Jacobson, Garth, Wolfson, Tanya, Gamst, Anthony, Schwimmer, Jeffrey B, Reeder, Scott B, Sirlin, Claude B |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Non-alcoholic fat liver disease screening and diagnosis Liver Disease Biopsy Middle Aged Sensitivity and Specificity Oral and gastrointestinal Detection Computer-Assisted Magnetic resonance imaging Liver Non-alcoholic Fatty Liver Disease Clinical Research Biomedical Imaging Humans Female Obesity Prospective Studies Protons Digestive Diseases Image Interpretation 4.2 Evaluation of markers and technologies Aged |
| Zdroj: | Abdominal radiology (New York), vol 45, iss 3 |
| Popis: | PurposeMRI proton density fat fraction (PDFF) can be calculated using magnitude (MRI-M) or complex (MRI-C) MRI data. The purpose of this study was to identify, assess, and compare the accuracy of common PDFF thresholds for MRI-M and MRI-C for assessing hepatic steatosis in patients with obesity, using histology as reference.MethodsThis two-center prospective study included patients undergoing MRI-C- and MRI-M-PDFF estimations within 3days before weight loss surgery. Liver biopsy was performed, and histology-determined steatosis grades were used as reference standard. Using receiver operating characteristics (ROC) analysis on data pooled from both methods, single common thresholds for diagnosing and differentiating none or mild (0-1) from moderate to severe steatosis (2-3) were selected as the ones achieving the highest sensitivity while providing at least 90% specificity. Selection methods were cross-validated. Performances were compared using McNemar's tests.ResultsOf 81 included patients, 54 (67%) had steatosis. The common PDFF threshold for diagnosing steatosis was 5.4%, which provided a cross-validated 0.88 (95% CI 0.77-0.95) sensitivity and 0.92 (0.75-0.99) specificity for MRI-M and 0.87 sensitivity (0.75-0.94) with 0.81 (0.61-0.93) specificity for MRI-C. The common PDFF threshold to differentiate steatosis grades 0-1 from 2 to 3 was 14.7%, which provided cross-validated 0.86 (95% CI 0.59-0.98) sensitivity and 0.95 (0.87-0.99) specificity for MRI-M and 0.93 sensitivity (0.68-0.99) with 0.97(0.89-0.99) specificity for MRI-C.ConclusionIf independently validated, diagnostic thresholds of 5.4% and 14.7% could be adopted for both techniques for detecting and differentiating none to mild from moderate to severe steatosis, respectively, with high diagnostic accuracy. |
| Databáze: | OpenAIRE |
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