Repeatability and accuracy of various region-of-interest sampling strategies for hepatic MRI proton density fat fraction quantification
| Autor: | Hong, Cheng William, Cui, Jennifer Y, Batakis, Danielle, Xu, Yang, Wolfson, Tanya, Gamst, Anthony C, Schlein, Alexandra N, Negrete, Lindsey M, Middleton, Michael S, Hamilton, Gavin, Loomba, Rohit, Schwimmer, Jeffrey B, Fowler, Kathryn J, Sirlin, Claude B |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male QIB Liver Disease Reproducibility of Results Magnetic Resonance Imaging Quantitative imaging biomarker Sampling strategy Young Adult Liver Non-alcoholic Fatty Liver Disease Hepatic fat quantification Humans Biomedical Imaging Prospective Studies Repeatability Protons Hepatic PDFF Digestive Diseases Region-of-interest |
| Zdroj: | Abdominal radiology (New York), vol 46, iss 7 |
| Popis: | PurposeTo evaluate repeatability of ROI-sampling strategies for quantifying hepatic proton density fat fraction (PDFF) and to assess error relative to the 9-ROI PDFF.MethodsThis was a secondary analysis in subjects with known or suspected nonalcoholic fatty liver disease who underwent MRI for magnitude-based hepatic PDFF quantification. Each subject underwent three exams, each including three acquisitions (nine acquisitions total). An ROI was placed in each hepatic segment on the first acquisition of the first exam and propagated to other acquisitions. PDFF was calculated for each of 511 sampling strategies using every combination of 1, 2, …, all 9 ROIs. Intra- and inter-exam intra-class correlation coefficients (ICCs) and repeatability coefficients (RCs) were estimated for each sampling strategy. Mean absolute error (MAE) was estimated relative to the 9-ROI PDFF. Strategies that sampled both lobes evenly ("balanced") were compared with those that did not ("unbalanced") using two-sample t tests.ResultsThe 29 enrolled subjects (23 male, mean age 24years) had mean 9-ROI PDFF 11.8% (1.1-36.3%). With more ROIs, ICCs increased, RCs decreased, and MAE decreased. Of the 60 balanced strategies with 4 ROIs, all (100%) achieved inter- and intra-exam ICCs > 0.998, 55 (92%) achieved intra-exam RC |
| Databáze: | OpenAIRE |
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