Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma
| Autor: | Israel, E, Drazen, JM, Liggett, SB, Boushey, HA, Cherniack, RM, Chinchilli, VM, Cooper, DM, Fahy, JV, Fish, JE, Ford, JG, Kraft, M, Kunselman, S, Lazarus, SC, Lemanske, RF, Martin, RJ, McLean, DE, Peters, SP, Silverman, EK, Sorkness, CA, Szefler, SJ, Weiss, ST, Yandava, CN, National Heart, Lung, and Blood Institute's Asthma Clinical Research Network |
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| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male beta(2)-adrenergic receptor Polymorphism Genetic Time Factors Genotype Adolescent Allergy Immunology Peak Expiratory Flow Rate Adrenergic beta-Agonists asthma albuterol beta(2)-adrenergic agonists respiratory tract diseases Cohort Studies immune system diseases Humans Female Receptors Adrenergic beta-2 National Heart Lung and Blood Institute's Asthma Clinical Research Network Child |
| Zdroj: | Israel, E; Drazen, JM; Liggett, SB; Boushey, HA; Cherniack, RM; Chinchilli, VM; et al.(2001). Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma.. International archives of allergy and immunology, 124(1-3), 183-186. doi: 10.1159/000053705. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3k75x163 |
| Popis: | Regular use of inhaled beta-adrenergic agonists may have adverse effects in some asthma patients. Polymorphisms of the beta(2)-adrenergic receptor (beta(2)-AR) can affect its regulation; however, results of smaller studies of the effects of such polymorphisms on response to beta-agonist therapy have been inconsistent.We examined the possible effects of polymorphisms at codons 16 (beta(2)-AR-16) and 27 (beta(2)-AR-27) on response to albuterol by genotyping 190 asthmatics who had participated in a trial of regular versus as-needed albuterol use.During the 16-week treatment period, patients homozygous for arginine (Arg/Arg) at beta(2)-AR-16 who used albuterol regularly had a small decline in morning peak expiratory flow (AM PEF). This effect was magnified during a 4-week run-out period, when all patients returned to as-needed albuterol only. By the end of the study, Arg/Arg subjects who had used albuterol regularly had an AM PEF 30.5 +/- 12.1 liters/min lower (p = 0.012) than Arg/Arg patients who had used albuterol as needed only. Subjects homozygous for glycine at beta(2)-AR-16 showed no such decline. Evening PEF also declined in the Arg/Arg regular but not in as-need albuterol users. No significant differences between regular and as-needed treatment were associated with polymorphisms at beta(2)-AR-27.Polymorphisms of the beta(2)-AR may influence airway responses to regular inhaled beta-agonist treatment. |
| Databáze: | OpenAIRE |
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