Effects of HIV Infection on Arterial Endothelial Function: Results From a Large Pooled Cohort Analysis
| Autor: | Stein, James H, Kime, Noah, Korcarz, Claudia E, Ribaudo, Heather, Currier, Judith S, Delaney, Joseph C |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Brachial Artery Adolescent Clinical Trials and Supportive Activities Clinical Sciences HIV Infections Cardiorespiratory Medicine and Haematology Severity of Illness Index Risk Assessment arteries complex traits Genome Wide Association Studies Young Adult Predictive Value of Tests Clinical Research Vascular HIV Seronegativity HIV Seropositivity Humans Endothelium AIDS-Associated Nephropathy Aged viremia human immunodeficiency virus Prevention lincRNAs creatinine AIDS Serodiagnosis Middle Aged cardiovascular diseases Vasodilation Infectious Diseases Good Health and Well Being Cardiovascular System & Hematology Heart Disease Risk Factors Case-Control Studies syntenic conservation HIV/AIDS Female Infection |
| Zdroj: | Arteriosclerosis, thrombosis, and vascular biology, vol 41, iss 1 |
| Popis: | ObjectiveTo determine the effects of HIV serostatus and disease severity on endothelial function in a large pooled cohort study of people living with HIV infection and HIV- controls. Approach and Results: We used participant-level data from 9 studies: 7 included people living with HIV (2 treatment-naïve) and 4 had HIV- controls. Brachial artery flow-mediated dilation (FMD) was measured using a standardized ultrasound imaging protocol with central reading. After data harmonization, multiple linear regression was used to examine the effects of HIV- serostatus, HIV disease severity measures, and cardiovascular disease risk factors on FMD. Of 2533 participants, 986 were people living with HIV (mean 44.4 [SD 11.8] years old) and 1547 were HIV- controls (42.9 [12.2] years old). The strongest and most consistent associates of FMD were brachial artery diameter, age, sex, and body mass index. The effect of HIV+ serostatus on FMD was strongly influenced by kidney function. In the highest tertile of creatinine (1.0 mg/dL), the effect of HIV+ serostatus was strong (β=-1.59% [95% CI, -2.58% to -0.60%], P=0.002), even after covariate adjustment (β=-1.36% [95% CI, -2.46% to -0.47%], P=0.003). In the lowest tertile (0.8 mg/dL), the effect of HIV+ serostatus was strong (β=-1.90% [95% CI, -2.58% to -1.21%], P |
| Databáze: | OpenAIRE |
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