| Autor: |
Volkow, ND, Wang, GJ, Newcorn, JH, Kollins, SH, Wigal, TL, Telang, F, Fowler, JS, Goldstein, RZ, Klein, N, Logan, J, Wong, C, Swanson, JM |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Volkow, ND; Wang, GJ; Newcorn, JH; Kollins, SH; Wigal, TL; Telang, F; et al.(2011). Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. Molecular Psychiatry, 16(11), 1147-1154. doi: 10.1038/mp.2010.97. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8m80p77v |
| DOI: |
10.1038/mp.2010.97. |
| Popis: |
Attention-deficit hyperactivity disorder (ADHD) is typically characterized as a disorder of inattention and hyperactivity/impulsivity but there is increasing evidence of deficits in motivation. Using positron emission tomography (PET), we showed decreased function in the brain dopamine reward pathway in adults with ADHD, which, we hypothesized, could underlie the motivation deficits in this disorder. To evaluate this hypothesis, we performed secondary analyses to assess the correlation between the PET measures of dopamine D2/D3 receptor and dopamine transporter availability (obtained with [11C]raclopride and [11C]cocaine, respectively) in the dopamine reward pathway (midbrain and nucleus accumbens) and a surrogate measure of trait motivation (assessed using the Achievement scale on the Multidimensional Personality Questionnaire or MPQ) in 45 ADHD participants and 41 controls. The Achievement scale was lower in ADHD participants than in controls (11±5 vs 14±3, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
