The association between p,p'-DDE levels and left ventricular mass is mainly mediated by obesity
| Autor: | La Merrill, MA, Lind, PM, Salihovic, S, van Bavel, B, Lind, L |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male Insecticides Heart Ventricles Dichlorodiphenyl Dichloroethylene Cardiovascular Toxicology Cohort Studies Risk Factors Clinical Research Prevalence 80 and over Humans 2.1 Biological and endogenous factors Obesity Aetiology Aged Adiposity Nutrition Sweden p '-DDE Left ventricular hypertrophy Hypertrophy Biological Sciences Left Ventricular Glucose Hypertension Chemical Sciences Environmental Pollutants Female Environmental Sciences p′-DDE |
| Popis: | BACKGROUND AND OBJECTIVES:The pesticide metabolite p,p'-DDE has been associated with left ventricular (LV) mass and known risk factors for LV hypertrophy in humans and in experimental models. We hypothesized that the associations of p,p'-DDE with LV hypertrophy risk factors, namely elevated glucose, adiposity and hypertension, mediate the association of p,p'-DDE with LV mass. METHODS:p,p'-DDE was measured in plasma from 70-year-old subjects (n = 988) of the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). When these subjects were 70-, 75- and 80- years old, LV characteristics were measured by echocardiography, while fasting glucose, body mass index (BMI) and blood pressure were assessed with standard clinical techniques. RESULTS:We found that p,p'-DDE levels were associated with increased fasting glucose, BMI, hypertension and LV mass in separate models adjusted for sex. Structural equation modeling revealed that the association between p,p'-DDE and LV mass was almost entirely mediated by BMI (70%), and also by hypertension (19%). CONCLUSION:The obesogenic effect of p,p'-DDE is a major determinant responsible for the association of p,p'-DDE with LV mass. |
| Databáze: | OpenAIRE |
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