Synthesis of [18 F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones

Autor: Narayanam, Maruthi Kumar, Ma, Gaoyuan, Champagne, Pier Alexandre, Houk, Kendall N, Murphy, Jennifer M
Rok vydání: 2017
Předmět:
Zdroj: Angewandte Chemie (International ed. in English), vol 56, iss 42
Popis: A practical method for radiofluorination of anilines with [18 F]fluoride via N-arylsydnone intermediates is described. These precursors are stable, easy to handle and facilitate direct and regioselective 18 F-labeling to prepare [18 F]fluoroarenes. The value of this methodology is further highlighted by successful application to prepare an 18 F-labeled neuropeptide.
Databáze: OpenAIRE