Comparative efficacy of an optimal exam between ultrasound versus abbreviated MRI for HCC screening in NAFLD cirrhosis: A prospective study
| Autor: | Huang, Daniel Q, Fowler, Kathryn J, Liau, Joy, Cunha, Guilherme M, Louie, Ashley L, An, Julie Y, Bettencourt, Ricki, Jung, Jinho, Gitto, Zachary, Hernandez, Christie, Lopez, Scarlett J, Gupta, Hersh, Sirlin, Claude B, Marks, Robert M, Loomba, Rohit |
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| Rok vydání: | 2022 |
| Předmět: |
Liver Cirrhosis
Male Liver Cancer Chronic Liver Disease and Cirrhosis Clinical Sciences Contrast Media Oral and gastrointestinal Hepatitis Rare Diseases Non-alcoholic Fatty Liver Disease Clinical Research NAFLD Humans Prospective Studies Retrospective Studies Cancer abbreviated MRI Gastroenterology & Hepatology cirrhosis Prevention Liver Disease Carcinoma Liver Neoplasms Hepatocellular hepatocellular carcinoma Pharmacology and Pharmaceutical Sciences Middle Aged Magnetic Resonance Imaging surveillance Biomedical Imaging Female Digestive Diseases |
| Zdroj: | Alimentary pharmacology & therapeutics, vol 55, iss 7 |
| Popis: | BackgroundRetrospective studies report that visualisation of the liver may be severely limited using ultrasound (US), potentially contributing to diminished sensitivity for detection of hepatocellular carcinoma (HCC) among patients with nonalcoholic fatty liver disease (NAFLD) and cirrhosis, but there are limited prospective data.AimsTo compare liver visualisation scores prospectively for US and abbreviated hepatobiliary phase (HBP) magnetic resonance imaging (AMRI) in a cohort of participants with NAFLD cirrhosis and a clinical indication for HCC surveillance.MethodsThis prospective multicenter study included 54 consecutive participants (67% women) with NAFLD cirrhosis who underwent contemporaneous US as well as HBP-AMRI with gadoxetic acid. Primary outcome was the proportion of imaging examinations with severe limitations in liver visualisation (visualisation score C) compared head-to-head between US and AMRI.ResultsThe mean (± standard deviation) age was 63.3years (±8.4) and body mass index was 32.0kg/m2 (±6.0). Nineteen participants (35%) had severe visualisation limitations on US, compared with 10 (19%) with AMRI, p |
| Databáze: | OpenAIRE |
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