Kidney Stones as an Underrecognized Clinical Sign in Pediatric Cushing Disease
| Autor: | Rahman, Sara H, Papadakis, Georgios Z, Keil, Margaret F, Faucz, Fabio R, Lodish, Maya B, Stratakis, Constantine A |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pediatric Urologic Diseases Kidney Disease Adolescent Renal and urogenital Human Movement and Sports Sciences Pediatrics X-Ray Computed Paediatrics and Reproductive Medicine Kidney Calculi Risk Factors Clinical Research Prevalence Humans Female Pituitary ACTH Hypersecretion Child Tomography Retrospective Studies |
| Popis: | ObjectiveTo investigate the prevalence of kidney stones in a population of children with Cushing disease (CD) and to compare it with the prevalence of kidney stones in healthy children.Study designClinical and biochemical data from 139 pediatric patients with CD (68 females, 71 males) were analyzed retrospectively. Computed tomography scans were reviewed for kidney stones.ResultsAmong 139 patients, 27 with CD (19.4%) had either radiographic evidence and/or a history of kidney stones. Those with kidney stones had higher urine free cortisol (P = .008) and transsphenoidal surgery at an older age (P = .007). The average urinary calcium/creatinine ratio was elevated in patients with CD (0.22 ± 0.11). The prevalence of kidney stones was higher in children with CD than in normal children (19.42% vs 1.0%; P < .001).ConclusionOur results illustrate that kidney stones are an underestimated complication of pediatric CD, especially when compared with the prevalence of nephrolithiasis in the general pediatric population. Long-term consequences for kidney function are not known and need to be studied. |
| Databáze: | OpenAIRE |
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