Human herpesvirus 8-unrelated primary effusion lymphoma-like lymphoma: report of a rare case and review of 54 cases in the literature
| Autor: | Wu, W, Youm, W, Rezk, SA, Zhao, X |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
B-Lymphocytes
KSHV/HHV-8–unrelated lymphoma viruses virus diseases Primary effusion lymphoma PEL biochemical phenomena metabolism and nutrition Effusion-based lymphoma Immunophenotyping Body cavity–based lymphoma immune system diseases hemic and lymphatic diseases Lymphoma Primary Effusion PEL-like lymphoma Herpesvirus 8 Human Humans KSHV/HHV-8–negative lymphoma Female Aged |
| Zdroj: | Wu, W; Youm, W; Rezk, SA; & Zhao, X. (2013). Human herpesvirus 8-unrelated primary effusion lymphoma-like lymphoma: report of a rare case and review of 54 cases in the literature.. Am J Clin Pathol, 140(2), 258-273. doi: 10.1309/AJCPHZ3CHO4HUWET. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8p04m230 |
| DOI: | 10.1309/AJCPHZ3CHO4HUWET. |
| Popis: | OBJECTIVES: To report a patient with primary effusion lymphoma who was negative for human herpesvirus-8 (HHV-8), human immunodeficiency virus, Epstein-Barr virus, hepatitis C virus, and hepatitis B virus, as well as review 54 reported cases of HHV-8-unrelated primary effusion lymphoma (PEL)-like lymphoma in the literature to clarify the nature of this entity. METHODS: The patients' characteristics, clinical presentation, pathogenesis, morphologic-immunophenotypic features, clinical management, and prognosis were studied. RESULTS: HHV-8-negative PEL-like lymphomas often occur in immunocompetent and elderly patients, are sometimes associated with chronic inflammation-related fluid overload, are mostly large B-cell or large B-cell with plasmacytic differentiation type, and are associated with a better prognosis. CONCLUSIONS: In various aspects, HHV-8-unrelated PEL-like lymphoma is a different entity from HHV-8-related PEL. Immunophenotype, morphology, and c-myc/8q24 status should be included for differential diagnosis. A test for c-myc or 8q24 abnormalities should be recommended for subdividing HHV-8-unrelated PEL-like lymphoma, which may have benefits in patient management. |
| Databáze: | OpenAIRE |
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