Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory
| Autor: | Swift, Kevin M, Gross, Brooks A, Frazer, Michelle A, Bauer, David S, Clark, Kyle JD, Vazey, Elena M, Aston-Jones, Gary, Li, Yong, Pickering, Anthony E, Sara, Susan J, Poe, Gina R |
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| Rok vydání: | 2018 |
| Předmět: |
Male
NREM hippocampus optogenetic Basic Behavioral and Social Science Medical and Health Sciences reconsolidation Behavioral and Social Science Animals Hippocampal Theta Rhythm sleep Spatial Memory Memory Consolidation locus coeruleus Psychology and Cognitive Sciences Neurosciences Brain Long-Evans CA1 Region Electroencephalography spindle Biological Sciences Rats Mental Health Place Cells theta REM Slow-Wave Sleep Stages Sleep Research ripples Developmental Biology |
| Zdroj: | Current biology : CB, vol 28, iss 22 |
| Popis: | Sleep is critical for proper memory consolidation. The locus coeruleus (LC) releases norepinephrine throughout the brain except when the LC falls silent throughout rapid eye movement (REM) sleep and prior to each non-REM (NREM) sleep spindle. We hypothesize that these transient LC silences allow the synaptic plasticity that is necessary to incorporate new information into pre-existing memory circuits. We found that spontaneous LC activity within sleep spindles triggers a decrease in spindle power. By optogenetically stimulating norepinephrine-containing LC neurons at 2Hz during sleep, we reduced sleep spindle occurrence, as well as NREM delta power and REM theta power, without causing arousals or changing sleep amounts. Stimulating the LC during sleep following a hippocampus-dependent food location learning task interfered with consolidation of newly learned locations and reconsolidation of previous locations, disrupting next-day place cell activity. The LC stimulation-induced reduction in NREM sleep spindles, delta, and REM theta and reduced ripple-spindle coupling all correlated with decreased hippocampus-dependent performance on the task. Thus, periods of LC silence during sleep following learning are essential for normal spindle generation, delta and theta power, and consolidation of spatial memories. |
| Databáze: | OpenAIRE |
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