A Dominantly Acting Murine Allele of Mcm4 Causes Chromosomal Abnormalities and Promotes Tumorigenesis

Autor: Kogan, Scott, Bagley, BN, Keane, TM, Maklakova, VI, Marshall, JG, Lester, RA, Cancel, MM, Paulsen, AR, Bendzick, LE, Been, RA
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Kogan, Scott; Bagley, BN; Keane, TM; Maklakova, VI; Marshall, JG; Lester, RA; et al.(2012). A Dominantly Acting Murine Allele of Mcm4 Causes Chromosomal Abnormalities and Promotes Tumorigenesis. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/61f265q5
Popis: Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/lymphoma (T-ALL) called Spontaneous dominant leukemia (Sdl). Sdl heterozygous mice develop disease with a short latency and high penetrance, while mice homozygous fo
Databáze: OpenAIRE