| Autor: |
Kristal, AR, Darke, AK, Morris, JS, Tangen, CM, Goodman, PJ, Thompson, IM, Meyskens, FL, Goodman, GE, Minasian, LM, Parnes, HL, Lippman, SM, Klein, EA |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Kristal, AR; Darke, AK; Morris, JS; Tangen, CM; Goodman, PJ; Thompson, IM; et al.(2014). Baseline selenium status and effects of selenium and vitamin E supplementation on prostate cancer risk. Journal of the National Cancer Institute, 106(3). doi: 10.1093/jnci/djt456. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7s6167sm |
| Popis: |
Background The Selenium and Vitamin E Cancer Prevention Trial found no effect of selenium supplementation on prostate cancer (PCa) risk but a 17% increased risk from vitamin E supplementation. This case-cohort study investigates effects of selenium and vitamin E supplementation conditional upon baseline selenium status. Methods There were 1739 total and 489 high-grade (Gleason 7-10) PCa cases and 3117 men in the randomly selected cohort. Proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for effects of supplementation within quintiles of baseline toenail selenium. Cox proportional hazards models were used to estimate hazard ratios, and all statistical tests are two-sided. Results Toenail selenium, in the absence of supplementation, was not associated with PCa risk. Selenium supplementation (combined selenium only and selenium + vitamin E arms) had no effect among men with low selenium status ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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