| Autor: |
Sanchez-Roige, S, Fontanillas, P, Elson, SL, Pandit, A, Schmidt, EM, Foerster, JR, Abecasis, GR, Gray, JC, De Wit, H, Davis, LK, MacKillop, J, Palmer, AA |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Zdroj: |
Sanchez-Roige, S; Fontanillas, P; Elson, SL; Pandit, A; Schmidt, EM; Foerster, JR; et al.(2018). Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. Nature Neuroscience, 21(1), 16-20. doi: 10.1038/s41593-017-0032-x. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7vj1h8df |
| Popis: |
© 2017 The Author(s). Delay discounting (DD), the tendency to discount the value of delayed versus current rewards, is elevated in a constellation of diseases and behavioral conditions. We performed a genome-wide association study of DD using 23,127 research participants of European ancestry. The most significantly associated single-nucleotide polymorphism was rs6528024 (P = 2.40 × 10-8), which is located in an intron of the gene GPM6B. We also showed that 12% of the variance in DD was accounted for by genotype and that the genetic signature of DD overlapped with attention-deficit/hyperactivity disorder, schizophrenia, major depression, smoking, personality, cognition and body weight. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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