High-Density, Long-Lasting, and Multi-region Electrophysiological Recordings Using Polymer Electrode Arrays
| Autor: | Chung, Jason E, Joo, Hannah R, Fan, Jiang Lan, Liu, Daniel F, Barnett, Alex H, Chen, Supin, Geaghan-Breiner, Charlotte, Karlsson, Mattias P, Karlsson, Magnus, Lee, Kye Y, Liang, Hexin, Magland, Jeremy F, Pebbles, Jeanine A, Tooker, Angela C, Greengard, Leslie F, Tolosa, Vanessa M, Frank, Loren M |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Polymers polymer 1.1 Normal biological development and functioning Bioengineering probe spike sorting massively parallel Underpinning research multi-electrode recording Animals Psychology rat modular Electrodes single neuron Neurology & Neurosurgery Neurosciences Brain Long-Evans Rats Electrophysiological Phenomena freely behaving headstage Neurological Cognitive Sciences Implanted Nerve Net Biotechnology |
| Zdroj: | Neuron, vol 101, iss 1 |
| Popis: | The brain is a massive neuronal network, organized into anatomically distributed sub-circuits, with functionally relevant activity occurring at timescales ranging from milliseconds to years. Current methods to monitor neural activity, however, lack the necessary conjunction of anatomical spatial coverage, temporal resolution, and long-term stability to measure this distributed activity. Here we introduce a large-scale, multi-site, extracellular recording platform that integrates polymer electrodes with a modular stacking headstage design supporting up to 1,024 recording channels in freely behaving rats. This system can support months-long recordings from hundreds of well-isolated units across multiple brain regions. Moreover, these recordings are stable enough to track large numbers of single units for over a week. This platform enables large-scale electrophysiological interrogation of the fast dynamics and long-timescale evolution of anatomically distributed circuits, and thereby provides a new tool for understanding brain activity. |
| Databáze: | OpenAIRE |
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