Quantitative measurement of atheroma burden: reproducibility in serial studies of atherosclerotic femoral arteries
| Autor: | Wang, Yuting, Liu, Xinke, Haraldsson, Henrik, Zhu, Chengcheng, Ballweber, Megan, Gasper, Warren, Hatsukami, Thomas, Saloner, David |
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| Rok vydání: | 2020 |
| Předmět: |
Observer Variation
Femoral Aging Reproducibility of Results Black blood Bioengineering MR Atherosclerosis Cardiovascular Reproducibility Imaging Femoral Artery Nuclear Medicine & Medical Imaging Carotid Arteries Heart Disease Clinical Research Three-Dimensional Humans Biomedical Imaging Plaque Atherosclerotic |
| Zdroj: | Magma (New York, N.Y.), vol 33, iss 6 |
| Popis: | ObjectivesThis study aims to evaluate the reproducibility of measures of plaque morphology in serially acquired black-blood MRI of untreated atherosclerotic femoral arteries.Materials and methodsMR studies was obtained from 42 timepoints, on 12 patients with known femoral artery atherosclerosis. Images with a 3D isotropic FLASH with DANTE-prepared black blood contrast (DASH) at a 3-T scanner were acquired at baseline, within 1week, and at 1month. Six of the patients were scanned additionally at 6months. Inter-scan and inter-observer variations of arterial area/volume measurements were evaluated.ResultsMeasurement of vessel area, lumen area, wall area and wall volume showed inter-scan intraclass correlation coefficients (ICC) ranging from 0.92 to 0.97 for 3 scans, 0.91-0.97 for 4 scans, and inter-observer ICCs of 0.89-0.96. Among 3 scans, the coefficients of variance (CV) for the vessel area, lumen area, wall area and wall volume were 4.1%, 6.5%, 7.5%, and 4.4%. CVs among 4 scans ranged from 4.4% to 7.9%, and interobserver CVs ranged from 6.1% to 11.8% for the different area/volume measurements.ConclusionDASH MRI is useful for quantifying atherosclerotic vessel area and volume of femoral arteries with low variability among serial repeated scans and between observers. |
| Databáze: | OpenAIRE |
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