RAS Proteins and Their Regulators in Human Disease
| Autor: | Simanshu, Dhirendra K, Nissley, Dwight V, McCormick, Frank |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
1.1 Normal biological development and functioning
Medical and Health Sciences Congenital Abnormalities RAS in the membrane KRAS therapies CRAFT Underpinning research Yeasts Neoplasms KRAS Animals Humans 2.1 Biological and endogenous factors RAF1 RAS proteins Aetiology RASopathies Phylogeny Cancer RAS effectors Mental Disorders Cell Membrane Biological Sciences NF1 Mutation Generic health relevance Signal Transduction RAS-driven cancer Developmental Biology |
| Zdroj: | Cell, vol 170, iss 1 |
| Popis: | RAS proteins are binary switches, cycling between ON and OFF states during signal transduction. These switches are normally tightly controlled, but in RAS-related diseases, such as cancer, RASopathies,and many psychiatric disorders, mutations in the RAS genes or their regulators render RAS proteins persistently active. The structural basis of the switch and many of the pathwaysthat RAS controls are well known, but the precise mechanisms by which RAS proteins function are less clear. All RAS biology occurs in membranes: a precise understanding of RAS' interaction with membranes is essential to understand RAS action and to intervene in RAS-driven diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|