Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D
| Autor: | Sinha-Hikim, I, Duran, P, Shen, R, Lee, M, Friedman, TC, Davidson, MB |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Clinical Trials and Supportive Activities Clinical Sciences Body Mass Index Prediabetic State Placebos Endocrinology & Metabolism Clinical Research pre-diabetes Plasminogen Activator Inhibitor 1 Complementary and Integrative Health Humans vitamin D supplementation Vitamin D Insulin-Like Growth Factor I Metabolic and endocrine Nutrition Inflammation Interleukin-6 Prevention Diabetes Evaluation of treatments and therapeutic interventions Hispanic or Latino Middle Aged Vitamin D Deficiency Black or African American C-Reactive Protein hypovitaminosis D 6.1 Pharmaceuticals Dietary Supplements Female Biomarkers |
| Zdroj: | Hormone and metabolic research = Hormon-und Stoffwechselforschung = Hormones et metabolisme, vol 47, iss 4 |
| Popis: | Low vitamin D levels are associated with minority subjects, the metabolic syndrome, and inflammation. The effect of vitamin D supplementation on markers of inflammation has not been well studied. The aim of the study was to evaluate the effects of high doses of vitamin D supplementation for 1 year on serum biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Latino (n=69) and African-American (n=11) subjects who had both pre-diabetes and hypovitaminosis D with a mean age of 52.0 years, a BMI of 32.7 kg/m(2), and 70% of whom were females, were randomized to receive weekly doses (mean±SD) of vitamin D (85 300 IU±16 000) or placebo oil for 1 year. Serum levels of interleukin-6, tumor necrosis factor, highly sensitive C-reactive protein), plasminogen activator inhibitor 1, and insulin-like growth factor-1 were measured at baseline, 6, and 12 months. Serum 25-OH vitamin D levels of 22 ng/ml at baseline quickly rose to nearly 70 ng/ml in subjects receiving vitamin D and did not change in the placebo group. Two-way repeated measures ANOVA showed no differences between the 2 groups in any of the 5 selected parameters. High dose vitamin D supplementation for 1 year in minority subjects with pre-diabetes and hypovitaminosis D failed to affect serum biomarkers of inflammation.Clinical trial reg. no.: NCT00876928, clinicaltrials.gov. |
| Databáze: | OpenAIRE |
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