CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease
| Autor: | Shi, Min, Kovac, Andrej, Korff, Ane, Cook, Travis J, Ginghina, Carmen, Bullock, Kristin M, Yang, Li, Stewart, Tessandra, Zheng, Danfeng, Aro, Patrick, Atik, Anzari, Kerr, Kathleen F, Zabetian, Cyrus P, Peskind, Elaine R, Hu, Shu-Ching, Quinn, Joseph F, Galasko, Douglas R, Montine, Thomas J, Banks, William A, Zhang, Jing |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Aging Knockout Parkinson's disease Clinical Sciences tau Proteins Neural Cell Adhesion Molecule L1 Blood plasma Neurodegenerative Inbred C57BL Exosomes Alzheimer's Disease Mice Central nervous system protein efflux Central nervous system-derived exosomes Alzheimer Disease 80 and over Acquired Cognitive Impairment Animals Humans 2.1 Biological and endogenous factors Aetiology Aged Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Parkinson Disease Biological Transport Middle Aged Brain Disorders Blood-Brain Barrier Geriatrics Neurological Female Dementia Tau Biomarkers |
| Zdroj: | Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 12, iss 11 |
| Popis: | IntroductionAlzheimer's disease (AD) and Parkinson's disease (PD) involve tau pathology. Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.MethodsTau efflux from the brain to the blood was evaluated by administering radioactively labeled and unlabeled tau intracerebroventricularly in wild-type and tau knock-out mice, respectively. Central nervous system (CNS)-derived tau in L1CAM-containing exosomes was further characterized extensively in human plasma, including by single molecule array technology with 303 subjects.ResultsThe efflux of Tau, including a fraction via CNS-derived L1CAM exosomes, was observed in mice. In human plasma, tau was explicitly identified within L1CAM exosomes. In contrast to AD patients, L1CAM exosomal tau was significantly higher in PD patients than controls and correlated with cerebrospinal fluid tau.ConclusionsTau is readily transported from the brain to the blood. The mechanisms of CNS tau efflux are likely different between AD and PD. |
| Databáze: | OpenAIRE |
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