YAP promotes erlotinib resistance in human non-small cell lung cancer cells
| Autor: | Hsu, Ping-Chih, You, Bin, Yang, Yi-Lin, Zhang, Wen-Qian, Wang, Yu-Cheng, Xu, Zhidong, Dai, Yuyuan, Liu, Shu, Yang, Cheng-Ta, Li, Hui, Hu, Bin, Jablons, David M, You, Liang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Neoplastic
erlotinib Tumor Lung Neoplasms Hippo pathway Carcinoma epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance Oncology and Carcinogenesis Signal Transducing Drug Resistance Adaptor Proteins Antineoplastic Agents Phosphoproteins respiratory tract diseases Cell Line Erlotinib Hydrochloride Gene Expression Regulation yes-associated protein Humans Neoplasm heterocyclic compounds Non-Small-Cell Lung neoplasms non-small cell lung cancer Transcription Factors |
| Zdroj: | Oncotarget, vol 7, iss 32 |
| Popis: | Yes-associated protein (YAP) is a main mediator of the Hippo pathway, which promotes cancer development. Here we show that YAP promotes resistance to erlotinib in human non-small cell lung cancer (NSCLC) cells. We found that forced YAP overexpression through YAP plasmid transfection promotes erlotinib resistance in HCC827 (exon 19 deletion) cells. In YAP plasmid-transfected HCC827 cells, GTIIC reporter activity and Hippo downstream gene expression of AREG and CTGF increased significantly (P |
| Databáze: | OpenAIRE |
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