Prevalence of Prediabetes and Type 2 Diabetes in Children With Nonalcoholic Fatty Liver Disease
| Autor: | Newton, Kimberly P, Hou, Jiayi, Crimmins, Nancy A, Lavine, Joel E, Barlow, Sarah E, Xanthakos, Stavra A, Africa, Jonathan, Behling, Cynthia, Donithan, Michele, Clark, Jeanne M, Schwimmer, Jeffrey B, Nonalcoholic Steatohepatitis Clinical Research Network |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Adolescent Chronic Liver Disease and Cirrhosis Clinical Trials and Supportive Activities Comorbidity Severity of Illness Index Pediatrics Hepatitis Prediabetic State Paediatrics and Reproductive Medicine Non-alcoholic Fatty Liver Disease Clinical Research Diabetes Mellitus Prevalence Humans 2.1 Biological and endogenous factors Obesity Aetiology Child Metabolic and endocrine Nutrition Pediatric Liver Disease Prevention Diabetes Cross-Sectional Studies Nonalcoholic Steatohepatitis Clinical Research Network Female Insulin Resistance Digestive Diseases Type 2 |
| Zdroj: | JAMA pediatrics, vol 170, iss 10 |
| Popis: | ImportanceNonalcoholic fatty liver disease (NAFLD) is a major chronic liver disease in children in the United States and is associated with insulin resistance. In adults, NAFLD is also associated with type 2 diabetes. To our knowledge, the prevalence of type 2 diabetes in children with NAFLD is unknown.ObjectiveTo determine the prevalence of type 2 diabetes and prediabetes in children with NAFLD and assess type 2 diabetes and prediabetes as risk factors for nonalcoholic steatohepatitis (NASH).Design, setting, and participantsThis was a multicenter, cross-sectional study at 12 pediatric clinical centers across the United States participating in the National Institute of Diabetes and Digestive and Kidney Diseases NASH Clinical Research Network. Children younger than 18 years with biopsy-confirmed NAFLD enrolled in the NASH Clinical Research Network.Main outcomes and measuresThe presence of type 2 diabetes and prediabetes as determined by American Diabetes Association screening criteria using clinical history and fasting laboratory values.ResultsThere were 675 children with NAFLD included in the study with a mean age of 12.6 years and mean body mass index (calculated as weight in kilograms divided by height in meters squared) of 32.5. Most of the children were boys (480 of 675) and Hispanic (445 of 675).The estimated prevalence of prediabetes was 23.4% (95% CI, 20.2%-26.6%), and the estimated prevalence of type 2 diabetes was 6.5% (95% CI, 4.6%-8.4%). Girls with NAFLD had 1.6 (95% CI, 1.04-2.40) times greater odds of having prediabetes and 5.0 (95% CI, 2.49-9.98) times greater odds of having type 2 diabetes than boys with NAFLD. The prevalence of NASH was higher in those with type 2 diabetes (43.2%) compared with prediabetes (34.2%) or normal glucose (22%) (P |
| Databáze: | OpenAIRE |
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