Thigh muscle cross-sectional areas and strength in knees with early vs knees without radiographic knee osteoarthritis: a between-knee, within-person comparison
| Autor: | Ruhdorfer, AS, Dannhauer, T, Wirth, W, Cotofana, S, Roemer, F, Nevitt, M, Eckstein, F, OAI investigators |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Clinical Sciences Biomedical Engineering Quadriceps Muscle Magnetic resonance imaging Clinical Research Osteoarthritis Humans Cross-sectional area Knee Muscle Strength Aged Arthritis Pain Research Rehabilitation Osteophyte Skeletal Organ Size Human Movement and Sports Sciences Middle Aged Arthritis & Rheumatology Radiography OAI investigators Thigh Case-Control Studies Musculoskeletal Disease Progression Muscle Female Knee osteoarthritis Strength Chronic Pain |
| Zdroj: | Osteoarthritis and cartilage, vol 22, iss 10 |
| Popis: | ObjectiveTo compare cross-sectional and longitudinal side-differences in thigh muscle anatomical cross-sectional areas (ACSAs), muscle strength, and specific strength (strength/ACSA), between knees with early radiographic change vs knees without radiographic knee osteoarthritis (RKOA), in the same person.Design55 (of 4796) Osteoarthritis Initiative (OAI) participants fulfilled the inclusion criteria of early RKOA in one limb (definite tibiofemoral osteophytes; no radiographic joint space narrowing [JSN]) vs no RKOA (no osteophyte; no JSN) in the contralateral limb. ACSAs of the thigh muscles and quadriceps heads were determined using axial MRIs at 33%/30% femoral length (distal to proximal). Isometric extensor and flexor muscle strength were measured (Good Strength Chair). Baseline quadriceps ACSA and extensor (specific) strength represented the primary analytic focus, and 2-year changes of quadriceps ACSAs the secondary focus.ResultsNo statistically significant side-differences in quadriceps (or other thigh muscle) ACSAs, muscle strength, or specific strength were observed between early RKOA vs contralateral limbs without RKOA (P ≥ 0.44), neither in men nor in women. The 2-year reduction in quadriceps ACSA in limbs with early RKOA was -0.9 ± 6% (mean ± standard deviation) vs -0.5 ± 6% in limbs without RKOA (statistical difference P = 0.85).ConclusionOur results do not provide evidence that early unilateral radiographic changes, i.e., presence of osteophytes, are associated with cross-sectional or longitudinal differences in quadriceps muscle status compared with contralateral knees without RKOA. At the stage of early unilateral RKOA there thus appears to be no clinical need for countervailing a potential dys-balance in quadriceps ACSAs and strength between both knees. |
| Databáze: | OpenAIRE |
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