Circulating Vitamin K Is Inversely Associated with Incident Cardiovascular Disease Risk among Those Treated for Hypertension in the Health, Aging, and Body Composition Study (Health ABC)
| Autor: | Shea, M Kyla, Booth, Sarah L, Weiner, Daniel E, Brinkley, Tina E, Kanaya, Alka M, Murphy, Rachel A, Simonsick, Eleanor M, Wassel, Christina L, Vermeer, Cees, Kritchevsky, Stephen B, Health ABC Study |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Aging and promotion of well-being hypertension Myocardial Ischemia Myocardial Infarction Cardiovascular vitamin K phylloquinone Food Sciences Animal Production Risk Factors cardiovascular disease Clinical Research Health ABC Study Humans 3.3 Nutrition and chemoprevention Antihypertensive Agents Proportional Hazards Models Aged Nutrition Extracellular Matrix Proteins Nutrition and Dietetics Nutrition & Dietetics matrix Gla protein Prevention Calcium-Binding Proteins Calcinosis Avitaminosis Vitamin K 1 Prevention of disease and conditions Stroke Heart Disease Good Health and Well Being Cardiovascular Diseases Body Composition Female |
| Zdroj: | The Journal of nutrition, vol 147, iss 5 |
| Popis: | Background: A role for vitamin K in coronary artery calcification (CAC), a subclinical manifestation of cardiovascular disease (CVD), has been proposed because vitamin K-dependent proteins, including the calcification inhibitor matrix Gla protein (MGP), are present in vascular tissue. Observational studies found that low circulating phylloquinone (vitamin K-1) was associated with increased CAC progression, especially in persons treated for hypertension. It is unknown whether hypertension treatment modifies this putative role of vitamin K in clinical CVD risk.Objective: We determined the association between vitamin K status and incident clinical CVD in older adults in the Health ABC (Health, Aging, and Body Composition Study) and whether the association differed by hypertension treatment status.Methods: Plasma phylloquinone was measured in 1061 participants free of CVD (70-79 y of age, 58% women, 39% black). Plasma uncarboxylated MGP [(dp)ucMGP] was measured in a subset of 635 participants. Multivariate Cox models estimated the HR for incident CVD over 12.1 follow-up years. Effect modification by hypertension was tested with the use of interaction terms.Results: Neither low plasma phylloquinone ( |
| Databáze: | OpenAIRE |
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