Association of HIV-1 Gag-Specific IgG Antibodies With Natural Control of HIV-1 Infection in Individuals Not Carrying HLA-B*57: 01 Is Only Observed in Viremic Controllers
| Autor: | Tjiam, M Christian, Morshidi, Mazmah A, Sariputra, Lucy, Martin, Jeffrey N, Deeks, Steven G, Tan, Dino BA, Lee, Silvia, Fernandez, Sonia, French, Martyn A |
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| Rok vydání: | 2017 |
| Předmět: |
Clinical Sciences
HIV Infections CD8-Positive T-Lymphocytes HIV Antibodies Viral Load Adaptive Immunity Lymphocyte Activation Virus Replication HIV Long-Term Survivors Good Health and Well Being HLA-B Antigens Immunoglobulin G Virology HIV-1 Disease Progression Public Health and Health Services Humans RNA Viral gag Gene Products Human Immunodeficiency Virus |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999), vol 76, iss 3 |
| Popis: | To expand upon our previous observation that HIV-1 Gag-specific IgG antibodies were highest in HIV controllers not carrying HLA-B*57:01, we analysed these antibodies in a larger cohort of viremic controllers (VCs) or elite controllers (ECs) considering carriage of ‘protective’ HLA-B alleles. HIV-1 p24-specific IgG1 and IgG2 antibodies were higher only in HLA-B*57:01− VCs but there were no differences in ECs. Associations of HIV-1 gp140-specific IgG antibodies with HLA-B*57:01 carriage were inconsistent amongst VCs and ECs. |
| Databáze: | OpenAIRE |
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