Prevalence of transactive response DNA-binding protein 43 (TDP-43) proteinopathy in cognitively normal older adults: systematic review and meta-analysis
| Autor: | Nascimento, C, Di Lorenzo Alho, AT, Bazan Conceição Amaral, C, Leite, REP, Nitrini, R, Jacob-Filho, W, Pasqualucci, CA, Hokkanen, SRK, Hunter, S, Keage, H, Kovacs, GG, Grinberg, LT, Suemoto, CK |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Aging
Neurology & Neurosurgery Prevention Clinical Sciences Neurosciences Brain Neurodegenerative brain ageing elderly Brain Disorders DNA-Binding Proteins Cognition TDP-43 Proteinopathies Neurological Prevalence Acquired Cognitive Impairment Humans TDP-43 proteinopathy Dementia Cognitive Sciences post mortem dementia |
| Zdroj: | Neuropathology and applied neurobiology, vol 44, iss 3 |
| Popis: | ObjectiveTo perform a systematic review and meta-analysis on the prevalence of transactive response DNA-binding protein 43 (TDP-43) proteinopathy in cognitively normal older adults.MethodsWe systematically reviewed and performed a meta-analysis on the prevalence of TDP-43 proteinopathy in older adults with normal cognition, evaluated by the Mini-Mental State Examination or the Clinical Dementia Rating. We estimated the overall prevalence of TDP-43 using random-effect models, and stratified by age, sex, sample size, study quality, antibody used to assess TDP-43 aggregates, analysed brain regions, Braak stage, Consortium to Establish a Registry for Alzheimer's Disease score, hippocampal sclerosis and geographic location.ResultsA total of 505 articles were identified in the systematic review, and 7 were included in the meta-analysis with 1196 cognitively normal older adults. We found an overall prevalence of TDP-43 proteinopathy of 24%. Prevalence of TDP-43 proteinopathy varied widely across geographic location (North America: 37%, Asia: 29%, Europe: 14%, and Latin America: 11%). Estimated prevalence of TDP-43 proteinopathy also varied according to study quality (quality score >7: 22% vs. quality score |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|