Examining if the relationship between BMI and incident type 2 diabetes among middle-older aged adults varies by race/ethnicity: evidence from the Multi-Ethnic Study of Atherosclerosis (MESA)
| Autor: | Rodriguez, LA, Bradshaw, PT, Shiboski, SC, Fernandez, A, Vittinghoff, E, Herrington, D, Ding, J, Kanaya, AM |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Aging Social Determinants of Health Clinical Sciences Cardiovascular Body Mass Index Cohort Studies Endocrinology & Metabolism Clinical Research Diabetes Mellitus Prevalence 80 and over Ethnicity Humans Psychology Metabolic and endocrine Aged Nutrition Incidence Prevention Diabetes Middle Aged Atherosclerosis United States Ethnic and Racial Minorities Public Health and Health Services Female Type 2 |
| Zdroj: | Diabetic medicine : a journal of the British Diabetic Association, vol 38, iss 5 |
| Popis: | AimsDisparities persist on the prevalence of undiagnosed type 2 diabetes in racial/ethnic minorities in the USA. This study evaluated the association between BMI and incident type 2 diabetes risk by racial/ethnic group, to determine whether BMI and presence of type 2 diabetes risk factors may help clinicians better target type 2 diabetes screening.MethodsThis prospective cohort analysis included 5659 adults free of type 2 diabetes at baseline from the Multi-Ethnic Study of Atherosclerosis (MESA), a population-based cohort (2000-2011). BMI was measured at baseline and time-updated at subsequent visits. Incident type 2 diabetes was defined as fasting glucose ≥7.0 mmol/l, or use of any diabetes medications.ResultsThe mean (sd) age was 62 (10)years and 42% of participants were white, 26% African American, 20% Hispanic and 12% Chinese American. During follow-up, 696 (12%) new type 2 diabetes cases were observed. In age- and sex-adjusted models, in the presence of one or more type 2 diabetes risk factors (the most common scenario), a 10% risk of incident type 2 diabetes was observed at a BMI of 21.7kg/m2 [95% confidence interval (CI) 20.1 to 22.8] in Chinese Americans, 23.8kg/m2 (22.7 to 24.9) in Hispanics, 24.7kg/m2 (23.7 to 25.6) in African Americans and 26.2kg/m2 (25.1 to 26.9) in white participants.ConclusionsThis study supports including BMI and presence of type 2 diabetes risk factors as action points for clinicians to prioritize which adults aged ≥45years should be screened. The application of race/ethnicity-specific BMI thresholds may reduce the disparity of undiagnosed type 2 diabetes observed in minority groups. |
| Databáze: | OpenAIRE |
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