| Autor: |
Sahar, S, Nin, V, Barbosa, MT, Chini, EN, Sassone-Corsi, P |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Zdroj: |
Sahar, S; Nin, V; Barbosa, MT; Chini, EN; & Sassone-Corsi, P. (2011). Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+oscillation. Aging, 3(8), 794-802. doi: 10.18632/aging.100368. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8gm4c6wv |
| Popis: |
The Intracellular levels of nicotinamide adenine dinucleotide (NAD+) are rhythmic and controlled by the circadian clock. However, whether NAD+oscillation in turn contributes to circadian physiology is not fully understood. To address this question we analyzed mice mutated for the NAD+ hydrolase CD38. We found that rhythmicity of NAD+was altered in the CD38-deficient mice. The high, chronic levels of NAD+results in several anomalies in circadian behavior and metabolism. CD38-null mice display a shortened period length of locomotor activity and alteration in the rest-activity rhythm. Several clock genes and, interestingly, genes involved in amino acid metabolism were deregulated in CD38-null livers. Metabolomic analysis identified alterations in the circadian levels of several amino acids, specifically tryptophan levels were reduced in the CD38-null mice at a circadian time paralleling with elevated NAD+levels. Thus, CD38 contributes to behavioral and metabolic circadian rhythms and altered NAD+levels influence the circadian clock. © Sassone-Corsi et al. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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