Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19
| Autor: | Matthay, Zachary A, Fields, Alexander T, Wick, Katherine D, Jones, Chayse, Lane, H Clifford, Herrera, Kimberly, Nuñez-Garcia, Brenda, Gennatas, Efstathios, Hendrickson, Carolyn M, Kornblith, Aaron E, Matthay, Michael A, Kornblith, Lucy Z, COVID-19 Associated Coagulopathy Inflammation Thrombosis (Co-ACIT) Study Group |
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| Rok vydání: | 2023 |
| Předmět: |
screening and diagnosis
COVID-19 Associated Coagulopathy Inflammation Thrombosis (Co-ACIT) Study Group SARS-CoV-2 Prevention Receptor for Advanced Glycation End Products Immunology COVID-19 biomarkers 4.1 Discovery and preclinical testing of markers and technologies Vaccine Related Detection Emerging Infectious Diseases Infectious Diseases Good Health and Well Being Medical Microbiology Clinical Research Biodefense thromboinflammation Humans Viral Antigens triage Infection Nucleocapsid |
| Popis: | IntroductionThere remains a need to better identify patients at highest risk for developing severe Coronavirus Disease 2019 (COVID-19) as additional waves of the pandemic continue to impact hospital systems. We sought to characterize the association of receptor for advanced glycation end products (RAGE), SARS-CoV-2 nucleocapsid viral antigen, and a panel of thromboinflammatory biomarkers with development of severe disease in patients presenting to the emergency department with symptomatic COVID-19.MethodsBlood samples were collected on arrival from 77 patients with symptomatic COVID-19, and plasma levels of thromboinflammatory biomarkers were measured.ResultsDifferences in biomarkers between those who did and did not develop severe disease or death 7 days after presentation were analyzed. After adjustment for multiple comparisons, RAGE, SARS-CoV-2 nucleocapsid viral antigen, interleukin (IL)-6, IL-10 and tumor necrosis factor receptor (TNFR)-1 were significantly elevated in the group who developed severe disease (all p80% on cut-point analysis.DiscussionElevated RAGE and SARS-CoV-2 nucleocapsid viral antigen on emergency department presentation are strongly associated with development of severe disease at 7 days. These findings are of clinical relevance for patient prognostication and triage as hospital systems continue to be overwhelmed. Further studies are warranted to determine the feasibility and utility of point-of care measurements of these biomarkers in the emergency department setting to improve patient prognostication and triage. |
| Databáze: | OpenAIRE |
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