| Autor: |
Gallegos, Anthony Cole, Davis, Michael James, Tchanque-Fossuo, Catherine N, West, Kaitlyn, Eisentrout-Melton, Angela, Peavy, Thomas R, Dixon, Roy W, Patel, Roma P, Dahle, Sara Evona, Isseroff, Roslyn Rivkah |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Advances in wound care, vol 8, iss 11 |
| Popis: |
Objective: There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic wound, compared with levels in patients after timolol ocular administration for the indication of glaucoma. Results: There was no statistically significant difference in the average plasma level of timolol in wound as compared with glaucoma patients. No bradycardia or wheezing was observed after administration. Innovation: We determined the single time point concentration of timolol in plasma 1 h after application of timolol 0.5% gel-forming solution to debrided chronic wounds, providing insight as to the safety of this emerging off-label treatment. Conclusion: The topical application of timolol for chronic wounds shares the same safety profile as the widely used application of ocular administration for glaucoma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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