Relationship between hippocampal atrophy and neuropathology markers: a 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol
| Autor: | Apostolova, Liana G, Zarow, Chris, Biado, Kristina, Hurtz, Sona, Boccardi, Marina, Somme, Johanne, Honarpisheh, Hedieh, Blanken, Anna E, Brook, Jenny, Tung, Spencer, Lo, Darrick, Ng, Denise, Alger, Jeffry R, Vinters, Harry V, Bocchetta, Martina, Duvernoy, Henri, Jack, Clifford R, Frisoni, Giovanni B, EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Amyloid Aging Image Processing Subfields Clinical Sciences tau Proteins Cell Count Neurodegenerative Alzheimer's Disease Hippocampus Computer-Assisted Alzheimer Disease CERAD 80 and over Pathology Acquired Cognitive Impairment Humans 2.1 Biological and endogenous factors Aetiology Aged Neurons validation Hippocampal atrophy Amyloid beta-Peptides Neuronal count Hippocampal volumes Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Organ Size Middle Aged Magnetic Resonance Imaging Temporal Lobe Benzoxazines Brain Disorders Geriatrics EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation Hippocampal segmentation Neurological Alzheimer Braak Biomedical Imaging Female Dementia Atrophy Tau |
| Zdroj: | Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 11, iss 2 |
| Popis: | ObjectiveThe pathologic validation of European Alzheimer's Disease Consortium Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP).MethodsTemporal lobes of nine Alzheimer's disease (AD) and seven cognitively normal subjects were scanned post-mortem at 7 Tesla. Hippocampal volumes were obtained with HarP. Six-micrometer-thick hippocampal slices were stained for amyloid beta (Aβ), tau, and cresyl violet. Hippocampal subfields were manually traced. Neuronal counts, Aβ, and tau burden for each hippocampal subfield were obtained.ResultsWe found significant correlations between hippocampal volume and Braak and Braak staging (ρ = -0.75, P = .001), tau (ρ = -0.53, P = .034), Aβ burden (ρ = -0.61, P = .012), and neuronal count (ρ = 0.77, P < .001). Exploratory subfield-wise significant associations were found for Aβ in Cornu Ammonis (CA)1 (ρ = -0.58, P = .019) and subiculum (ρ = -0.75, P = .001), tau in CA2 (ρ = -0.59, P = .016), and CA3 (ρ = -0.5, P = .047), and neuronal count in CA1 (ρ = 0.55, P = .028), CA3 (ρ = 0.65, P = .006), and CA4 (ρ = 0.76, P = .001).ConclusionsThe observed associations provide pathological confirmation of hippocampal morphometry as a valid biomarker for AD and pathologic validation of HarP. |
| Databáze: | OpenAIRE |
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