| Autor: |
Kawas, CH, Greenia, DE, Bullain, SS, Clark, CM, Pontecorvo, MJ, Joshi, AD, Corrada, MM |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Zdroj: |
Kawas, CH; Greenia, DE; Bullain, SS; Clark, CM; Pontecorvo, MJ; Joshi, AD; et al.(2013). Amyloid imaging and cognitive decline in nondemented oldest-old: The 90+ Study. Alzheimer's and Dementia, 9(2), 199-203. doi: 10.1016/j.jalz.2012.06.005. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3jd828n2 |
| DOI: |
10.1016/j.jalz.2012.06.005. |
| Popis: |
Background: The goal of this study was to examine cross-sectional and longitudinal associations between cognitive performance and beta amyloid (Aβ) load determined by florbetapir F18 positron emission tomography (PET) in nondemented oldest-old. Methods: Thirteen nondemented (normal or cognitively impaired nondemented) participants (median age, 94.2 years) from The 90+ Study underwent florbetapir-PET scanning within 3 months of baseline neuropsychological testing. Amyloid load was measured with a semi-automated quantitative analysis of average cortical-to-cerebellar standardized uptake value ratio (SUVr) and a visual interpretation (Aβ- or Aβ+). Neuropsychological testing was repeated every 6 months. Results: At baseline, SUVr correlated significantly with tests of global cognition and memory. During follow-up (median, 1.5 years), the Aβ+ group had steeper declines on most cognitive tests, particularly global cognitive measures. Conclusion: This preliminary study suggests that greater amyloid load is associated with poorer cognition and faster cognitive decline in nondemented oldest-old. Amyloid load may identify individuals at increased risk of developing Alzheimer's disease. © 2013 The Alzheimer's Association. All rights reserved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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