Development of potent inhibitors of pyocyanin production in Pseudomonas aeruginosa
| Autor: | Miller, Laura C, O'Loughlin, Colleen T, Zhang, Zinan, Siryaporn, Albert, Silpe, Justin E, Bassler, Bonnie L, Semmelhack, Martin F |
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| Rok vydání: | 2015 |
| Předmět: |
Molecular Structure
Cystic Fibrosis Pyridines Medicinal & Biomolecular Chemistry Organic Chemistry Microbial Sensitivity Tests Pharmacology and Pharmaceutical Sciences Amides Anti-Bacterial Agents Dose-Response Relationship Small Molecule Libraries Structure-Activity Relationship Medicinal and Biomolecular Chemistry Rare Diseases Infectious Diseases 5.1 Pharmaceuticals Pseudomonas aeruginosa Pyocyanine 2.2 Factors relating to the physical environment Drug Development of treatments and therapeutic interventions Aetiology Infection Lung |
| Zdroj: | Journal of medicinal chemistry, vol 58, iss 3 |
| Popis: | The development of new approaches for the treatment of antimicrobial-resistant infections is an urgent public health priority. The Pseudomonas aeruginosa pathogen, in particular, is a leading source of infection in hospital settings, with few available treatment options. In the context of an effort to develop antivirulence strategies to combat bacterial infection, we identified a series of highly effective small molecules that inhibit the production of pyocyanin, a redox-active virulence factor produced by P. aeruginosa. Interestingly, these new antagonists appear to suppress P. aeruginosa virulence factor production through a pathway that is independent of LasR and RhlR. |
| Databáze: | OpenAIRE |
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