Heterogeneous incidence and propagation of spreading depolarizations
| Autor: | Kaufmann, Dan, Theriot, Jeremy J, Zyuzin, Jekaterina, Service, C Austin, Chang, Joshua C, Tang, Y Tanye, Bogdanov, Vladimir B, Multon, Sylvie, Schoenen, Jean, Ju, Y Sungtaek, Brennan, KC |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Spreading depolarization velocity Neurology & Neurosurgery Cortical Spreading Depression Optical Imaging Clinical Sciences Hemodynamics Wavelet Analysis Neurosciences Brain anisotropy In Vitro Techniques Cardiorespiratory Medicine and Haematology Inbred C57BL susceptibility Rats Potassium Chloride Brain Disorders Mice Models Neurological Animals Sprague-Dawley |
| Zdroj: | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, vol 37, iss 5 |
| Popis: | Spreading depolarizations are implicated in a diverse set of neurologic diseases. They are unusual forms of nervous system activity in that they propagate very slowly and approximately concentrically, apparently not respecting the anatomic, synaptic, functional, or vascular architecture of the brain. However, there is evidence that spreading depolarizations are not truly concentric, isotropic, or homogeneous, either in space or in time. Here we present evidence from KCl-induced spreading depolarizations, in mouse and rat, invivo and invitro, showing the great variability that these depolarizations can exhibit. This variability can help inform the mechanistic understanding of spreading depolarizations, and it has implications for their phenomenology in neurologic disease. |
| Databáze: | OpenAIRE |
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