| Autor: |
Kianian, Bita |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Kianian, Bita. (2017). A Multimodal Microvascular Imaging System for the Rodent Dorsal Skinfold Window Chamber: Development, Validation and Application. UC Irvine: Biomedical Engineering. Retrieved from: http://www.escholarship.org/uc/item/3gt1r0f8 |
| Popis: |
Port wine stains (PWS) are congenital vascular malformation of the skin that occur in 3-4 infantsper 1000 live births. A major factor that contributes to treatment failures of Port wine stain(PWS) birthmarks is reperfusion of photocoagulated blood vessels due to wound healingresponse. The study of physiological processes that govern the microvasculature plays a majorrole in our ability to discover solutions toward enhancement of the current treatments to portwine stain and many other diseases. The functionality of microvasculature and their response toexternal influences is difficult to assess with the traditional analysis techniques such as histology.The work described in this thesis aims to provide a microvascular optical functional imagingsolution specifically designed for use with the rodent dorsal window chamber models.Our microvascular imaging system was designed to obtain images with three different imagingmodes: Laser speckle imaging (LSI), Multispectral Imaging/Oxygenation imaging (MSI/O2I)and Fluorescence imaging (FI). Each of these imaging techniques provides information about thedifferent aspects of microvessels. LSI is utilized to measure the relative changes in blood flow,MSI enables computation of hemoglobin saturation maps, and FI highlights biochemicalprocesses active in a subject. Our analysis showed that the developed imaging system thatcombines different imaging techniques could be used as a valuable tool to assess the behavior ofmicrovessels over time in response to external factors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
